New research reveals that patients who stop using blockbuster slimming jabs like semaglutide or tirzepatide may regain reduced body mass much more quickly than those who stop conventional diet and exercise plans.
Published data in a prominent medical journal demonstrates that while obese individuals can lose a large proportion of their total mass while using the jabs, the mass returns at an average rate of nearly a kilo each month once they quit.
"People buying these treatments should be informed of the danger of rapid weight regain when the treatment is stopped," stated researcher Dr. Susan Jebb.
That rate of recovery suggests a reversion to pre-treatment weight in about a year and a half.
Weighing Approaches
The study, which examined dozens of studies involving over 9,000 of participants, compared the effects of the injectable medications with older methods.
The team point out that people who shed pounds through diet and exercise typically see a less rapid creep back—around 100 grams monthly—once they finish.
Understanding the Fast Regain
Experts suggest the mechanism of the jabs explains the amplified weight return.
GLP-1 drugs mimic a natural hormone called GLP-1, which helps regulate appetite.
"Long-term administration of the hormone levels several times higher than the body's typical production might result in the body to generate a reduced amount of its endogenous hormone, and may also diminish sensitivity to its effects," said Dr. Adam Collins, a dietetics expert.
"Withdrawal of this medication means hunger is uncontrolled, making binge eating much more probable."
A Chronic Issue?
Health authorities recommend the injections for individuals with obesity-related health risks, alongside recommended diet and exercise modifications.
Many experts contend that, considering the significant potential of relapse, the treatment might need to be life-long.
This view is echoed by pharmaceutical companies, who say that the results "highlight the persistent character of obesity," similar to managing diseases like diabetes.
Patient Experiences
People who have stopped the medication explain a sudden return of appetite.
"It was like a trigger that goes on and you become extremely hungry," recalled one woman.
This difficulty is worsened if users have not adopted permanent dietary or behavioural changes during therapy.
Widespread Use
Figures indicate that a significant number of adults in the UK have used these injections in the past year, with demand continuing to grow.
- Use is greater among women compared to males.
- The 40s and 50s demographic shows the highest usage rates.
- Many obtain the medications through private healthcare rather than public health services.
Ultimately, researchers stress that while these medications are potent tools for shedding pounds, they are not a permanent cure and maintained weight loss likely depends on combined lifestyle management.
